![]() ![]() coli cells to LYS228 caused filamentation consistent with impaired cell division. coli PBP3, with weaker binding to PBP1a and PBP1b. A gel-based assay showed that LYS228 bound mainly to E. LYS228 bound purified Escherichia coli penicillin binding protein 3 (PBP3) similarly to aztreonam (derived acylation rate/equilibrium dissociation constant of 367,504 s -1 M -1 and 409,229 s -1 M -1, respectively) according to stopped-flow fluorimetry. However, the clinically used monobactam aztreonam lacks stability to serine β-lactamases (SBLs) that are often coexpressed with MBLs. The monobactam scaffold is attractive for the development of new agents to treat infections caused by drug-resistant Gram-negative bacteria because it is stable to metallo-β-lactamases (MBLs). ![]()
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